Inhaled Corticosteroid Comparative Dosing: Inhaled Corticosteroid Comparative Dosing (2024)

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Inhaled Corticosteroid Comparative Dosing

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Inhaled Corticosteroid Comparative Dosing
References

Inhaled Corticosteroid Comparative Dosing

The values listed below were obtained from the National Institutes of Health.^[1]

Beclomethasone HFA

Children aged 0-4 years
- Low dose: NA
- Medium dose: NA
- High dose: NA
Children aged 5-11 years
- Low dose: 80-160 µg
- Medium dose: 160-320 µg
- High dose: >320 µg
Individuals aged ≥12 years
- Low dose: 80-240 µg
- Medium dose: 240-480 µg
- High dose: >480 µg

Budesonide powder for inhalation^{[2, 3]}

Children aged 0-4 years
- Low dose: NA
- Medium dose: NA
- High dose: NA
Children aged 5-11 years
- Low dose: 180-400 µg
- Medium dose: 400-800 µg
- High dose: >800 µg
Individuals aged ≥12 years
- Low dose: 180-600 µg
- Medium dose: 600-1200 µg
- High dose: >1200 µg
  See Also
  Inhaled Corticosteroids Inhaled Corticosteroid Dose Comparison in Asthma - North & East

Budesonide inhalation suspension

Children aged 0-4 years
- Low dose: 0.25-0.5 mg
- Medium dose: 0.5-1 mg
- High dose: >1 mg
Children aged 5-11 years
- Low dose: 0.5 mg
- Medium dose: 1 mg
- High dose: 2 mg
Individuals aged ≥12 years
- Low dose: NA
- Medium dose: NA
- High dose: NA

Flunisolide

Children aged 0-4 years
- Low dose: NA
- Medium dose: NA
- High dose: NA
Children aged 5-11 years
- Low dose: 160 µg
- Medium dose: 320 µg
- High dose: >640 µg
Individuals aged ≥12 years
- Low dose: 320 µg
- Medium dose: 320-640 µg
- High dose: >640 µg

Fluticasone HFA/metered dose inhaler (MDI)^[4]

Children aged 0-4 years
- Low dose: 176 µg
- Medium dose: 176-352 µg
- High dose: 352 µg
Children aged 5-11 years
- Low dose: 88-176 µg
- Medium dose: 176-352 µg
- High dose: >352 µg
Individuals aged ≥12 years
- Low dose: 88-264 µg
- Medium dose: 264-440 µg
- High dose: >440 µg

Fluticasone dry powder inhaler (DPI)^[5]

Children aged 0-4 years
- Low dose: NA
- Medium dose: NA
- High dose: NA
Children aged 5-11 years
- Low dose: 100-200 µg
- Medium dose: 200-400 µg
- High dose: >400 µg
Individuals aged ≥12 years
- Low dose: 100-300 µg
- Medium dose: 300-500 µg
- High dose: >500 µg

Mometasone DPI

Children aged 0-4 years
- Low dose: NA
- Medium dose: NA
- High dose: NA
Children aged 5-11 years
- Low dose: NA
- Medium dose: NA
- High dose: NA
Individuals aged ≥12 years
- Low dose: 200 µg
- Medium dose: 400 µg
- High dose: >400 µg

References

[Guideline] National Institutes of Health. Estimated Comparative Daily Doses: Inhaled Corticosteroids for Long–Term Asthma Control. Guidelines from the National Asthma Education and Prevention Program: Expert Panel Report 3. NIH. Available at https://www.nhlbi.nih.gov/guidelines/asthma/asthma_qrg.htm#estimated-comparative-daily-doses. Accessed: May 13, 2014.
Liu T, Han M, Tian F, Cun D, Rantanen J, Yang M. Budesonide nanocrystal-loaded hyaluronic acid microparticles for inhalation: In vitro and in vivo evaluation. Carbohydr Polym. 2018 Feb 1. 181:1143-1152. [QxMD MEDLINE Link].
Miyazaki Y, Aruga N, Kadota K, Tozuka Y, Takeuchi H. Improved respirable fraction of budesonide powder for dry powder inhaler formulations produced by advanced supercritical CO₂ processing and use of a novel additive. Int J Pharm. 2017 Aug 7. 528 (1-2):118-126. [QxMD MEDLINE Link].
Kobayashi Y, Asako M, Yamamoto T, Yasuba H, Tomoda K, Kanda A. Replacement of SFC-DPI with SFC-MDI exhaled through the nose improves eosinophilic chronic rhinosinusitis in patients with bronchial asthma. Int J Clin Pharmacol Ther. 2017 Jan. 55 (1):89-94. [QxMD MEDLINE Link].
Sher LD, Yiu G, Sakov A, Liu S, Caracta CF. Fluticasone propionate and fluticasone propionate/salmeterol multidose dry powder inhalers compared with placebo for persistent asthma. Allergy Asthma Proc. 2017 Sep 21. 38 (5):343-353. [QxMD MEDLINE Link].

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Contributor Information and Disclosures

Author

Edward Charbek, MD, FCCP Associate Professor, Associate Director of Pulmonary and Critical Care Fellowship Program, Department of Internal Medicine, Division of Pulmonary-Critical Care and Sleep Medicine, SSM Health St Louis University Hospital; Medical Director, Kindred Hospital-St Louis

Edward Charbek, MD, FCCP is a member of the following medical societies: American College of Chest Physicians, American Thoracic Society, Association of Pulmonary and Critical Care Medicine Program Directors

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

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